Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease
✍ Scribed by Lorena De Mena; Eliecer Coto; Elena Sánchez-Ferrero; René Ribacoba; Luis M. Guisasola; Carlos Salvador; Marta Blázquez; Victoria Alvarez
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 239 KB
- Volume
- 116
- Category
- Article
- ISSN
- 1435-1463
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## Abstract Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized clinically by a combination of motor symptoms. Identifying novel PD genetic risk factors is important for understanding its pathogenesis. A recent study suggested that up to 21% of subjects with PD
## Abstract Multiple genes have been now identified as causing Parkinson's disease (PD). In 2003, two mutations were identified in exon 1 of the Nurr1 gene in 10 of 107 individuals with familial PD. To date, investigators have only focused on screening for these known mutations of the Nurr1 gene. A