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Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

✍ Scribed by Anni Aggerholm; Kirsten Grønbæk; Per Guldberg; Peter Hokland


Book ID
114422907
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
136 KB
Volume
65
Category
Article
ISSN
0902-4441

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Mutation analysis of PTEN/MMAC1 in acute
✍ Liu, Ta-Chih; Lin, Pai-Mei; Chang, Jan-Gowth; Lee, Jing-Ping; Chen, Tyen-Po; Lin 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB 👁 2 views

Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c