Mutation analysis of PTEN/MMAC1 in acute
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Liu, Ta-Chih; Lin, Pai-Mei; Chang, Jan-Gowth; Lee, Jing-Ping; Chen, Tyen-Po; Lin
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Article
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2000
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John Wiley and Sons
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English
⚖ 285 KB
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Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c