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Mutational analysis of the synapsin III gene on chromosome 22q12-q13 in schizophrenia

✍ Scribed by Tsuyuka Ohtsuki; Rie Ichiki; Michio Toru; Tadao Arinami


Book ID
118564165
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
228 KB
Volume
94
Category
Article
ISSN
0165-1781

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To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers on

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from genotyping of 3 dinucleotide repeat polymorphisms (at the loci D22S268, ILSRB, D22S307) for a combined replication sample of 256 families, each having 2 or more affected individuals with DNA, were analysed using a complex autosomal dominant model. This study provided no evidence for linkage or