Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1

✍ Scribed by Pulver, Ann E. ;Karayiorgou, Maria ;Wolyniec, Paula S. ;Lasseter, Virginia K. ;Kasch, Laura ;Nestadt, Gerald ;Antonarakis, Stylianos ;Housman, David ;Kazazian, Haig H. ;Meyers, Deborah ;Ott, Jurg ;Lamacz, Malgorzata ;Liang, Kung-Yee ;Hanfelt, John ;Ullrich, Gail ;DeMarchi, Nicola ;Ramu, Elango ;McHugh, Paul R. ;Adler, Lawrence ;Thomas, Marion ;Carpenter, William T. ;Manschreck, Theo ;Gordon, C. T. ;Kimberland, Michelle ;Babb, Robert ;Puck, Jennifer ;Childs, Barton

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 1000 KB
• Volume: 54
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.1320540108

✦ Synopsis

To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12-q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies.