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Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2

✍ Scribed by Pulver, Ann E. ;Karayiorgou, Maria ;Lasseter, Virginia K. ;Wolyniec, Paula ;Kasch, Laura ;Antonarakis, Stylianos ;Housman, David ;Kazazian, Haig H. ;Meyers, Deborah ;Nestadt, Gerald ;Ott, Jurg ;Liang, Kung-Yee ;Lamacz, Malgorzata ;Thomas, Marion ;Childs, Barton ;Diehl, Scott R. ;Wang, Shengbiao ;Murphy, Bernadette ;Sun, Cui-E ;O'Neill, F. Anthony ;Nie, Li ;Sham, Pak ;Burke, John ;Duke, Betty W. ;Duke, Fiona ;Kipps, Barbara R. ;Bray, Joseph ;Hunt, Wanda ;Shinkwin, Rosmarie ;Nuallain, Maurin Ni ;Su, Ying ;Maclean, Charles J. ;Walsh, Dermot ;Kendler, Kenneth S. ;Gill, Michael ;Vallada, Homero ;Mant, Rebecca ;Asherson, Philip ;Collier, David ;Parfitt, Elizabeth ;Roberts, Enriquetta ;Nanko, Shin ;Walsh, Cathy ;Daniels, Johanna ;Murray, Robin ;McGuffin, Peter ;Owen, Mike ;Laurent, Claudine ;Dumas, Jean-Baptiste ;d'Amato, Thierry ;Jay, Maurice ;Martinez, Maria ;Campion, Dominique ;Mallet, Jacques

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
842 KB
Volume
54
Category
Article
ISSN
0148-7299

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✦ Synopsis

from genotyping of 3 dinucleotide repeat polymorphisms (at the loci D22S268, ILSRB, D22S307) for a combined replication sample of 256 families, each having 2 or more affected individuals with DNA, were analysed using a complex autosomal dominant model. This study provided no evidence for linkage or heterogeneity for the region 22q12-ql3 under this model. We conclude that if this region confers susceptibility to schizophrenia, it must be in only a small proportion of families. Collaborative efforts to obtain large samples must continue to play an important role in the genetic search for clues to complex psychiatric disorders such as schizophrenia.

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