Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpression by immunohistochemistry using 3 monoclonal
Mutational Analysis of the Human p53 Gene in Malignant Melanoma
โ Scribed by VOLKENANDT, MATTHIAS ;SCHLEGEL, UWE ;NANUS, DAVID M. ;ALBINO, ANTHONY P.
- Book ID
- 111259463
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 664 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0893-5785
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A computerized database is described that contains information about 507 mutations in the p53 gene of hematologic tumors and corresponding cell lines. Analysis of these mutations indicated the following findings: First, mutational spectrum analysis in these tumors was found to be similar to the patt