Analysis of intron 4 of the p53 gene in human cutaneous melanoma
β Scribed by Monee Shamsher; Ximena Montano
- Book ID
- 116133501
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 322 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0378-1119
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## Abstract The abrogation of the function of the βgatekeeper of the genomeβ, p53, is the most prevalent molecular alteration in solid human tumors. Regarding melanomas the involvement of __p53__ alterations is discussed controversially to date. In order to evaluate the status of p53 in detail, pri
The frequency and significance of p53 alterations in cutaneous melanoma have not been completely clarified. In the present study, 31 primary melanomas of the nodular type and 15 metastases occurring between 1981 and 1983 were studied with respect to mutations in exons 7 and 8, as well as to p53 prot
The purpose of the present study was to examine the expression of p53 protein in malignant melanomas of the nodular sub-type, with special reference to the role of p53 alterations in the development of metastases. Increased expression of p53 protein was found in 29 of 30 cases using PAbl801 monoclon