✦ LIBER ✦

Flow cytometric analysis of p53 oncoprotein expression in cutaneous melanoma

✍ Scribed by A. J. Hayes; A. J. Oates; D. Ross; G. Wilson

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 218 KB
Volume: 84
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800841236

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Alterations and prognostic significance

Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma

✍ Oddbjørn Straume; Lars A. Akslen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 60 KB 👁 2 views

The role of p16 and p53 alterations in cutaneous melanoma has been recently discussed, but it remains to be clarified. In the present immunohistochemical study, the expression of p16 and p53 proteins and their possible prognostic relevance have been examined in 102 melanomas of the aggressive nodula

A novel flow cytometric method for the q

A novel flow cytometric method for the quantification of p53 gene expression

✍ Giuditta Filippini; Sayuri Griffin; Mario Uhr; Hans Eppenberger; Josè Bonilla; F 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 2 views

We describe a rapid and simple flow cytometry technique for the detection and quantification of p53 in several human cell lines, including an adenocarcinoma cell line (SW 626) having a mutant (m) p53, and a pre-B leukemia cell line (NALM-6) having wild-type (wt) p53. By introducing a second antibody

Frequent mutations of the p53 gene in cu

Frequent mutations of the p53 gene in cutaneous melanoma of the nodular type

✍ Lars A. Akslen; Sissel E. Monstad; Benedikte Larsen; Oddbjørn Straume; Dagfinn Ø 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 54 KB

The frequency and significance of p53 alterations in cutaneous melanoma have not been completely clarified. In the present study, 31 primary melanomas of the nodular type and 15 metastases occurring between 1981 and 1983 were studied with respect to mutations in exons 7 and 8, as well as to p53 prot

Discrepant flow cytometric expression an

Discrepant flow cytometric expression and function of P-glycoprotein in neuroblastic tumors

✍ B. De Moerloose; C. Dhooge; G. Laureys; Y. Benoit; M. Demarche; C. Devalck; D. P 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

Background: Patients suffering from neuroblastic tumors are currently being classified into prognostic subsets based on different clinical and biologic features. In this study, a triple-color flow cytometric assay and a functional test were applied to neuroblastoma cell lines and patients with a neu

Prognostic implications of p53 overexpre

Prognostic implications of p53 overexpression in cutaneous melanoma from sun-exposed and nonexposed sites

✍ Richard Essner; Christine T. Kuo; Hejing Wang; Duan R. Wen; Roderick R. Turner; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB 👁 2 views

mens were from primary tumors and 35 specimens were from lymph node, subcu-Wayne Cancer Institute, Santa Monica, Califortaneous, or visceral metastases. The chi-square test was used to assess the signifinia. cance of p53p overexpression, and the Cox proportional hazards model was used

Flow cytometric analysis of P-glycoprote

Flow cytometric analysis of P-glycoprotein expression and drug efflux in human soft tissue and bone sarcomas

✍ Hiroshi Kunikane; Mark M. Zalupski; Cheppail Ramachandran; Mark A. KuKuruga; Dav 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 85 KB

Twenty-two fresh surgical specimens of human sarcomas (soft tissue and bone) from 20 patients were analyzed by flow cytometry for the expression of drug resistance-related P-glycoprotein (P-gp) and cellular daunorubicin (DNR) accumulation with or without the presence of DNR efflux blockers. Single-c