Mutational Analysis of Human Papillomavirus Type 16 E6 Protein: Transforming Function for Human Cells and Degradation of p53 in Vitro
โ Scribed by Shunsuke Nakagawa; Sumie Watanabe; Hiroyuki Yoshikawa; Yuji Taketani; Kunito Yoshiike; Tadahito Kanda
- Book ID
- 112270685
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 511 KB
- Volume
- 212
- Category
- Article
- ISSN
- 0042-6822
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Certain types of human papillomavirus (HPV), such as types 16 and 18, are etiological agents for carcinogenesis of the uterine cervix. These HPVs have two oncogenes, E6 and E7, that have transforming activities in established murine cells. Tumorigenicity and decreased serum requirement for cell grow
## Abstract Certain types of human papillomavirus (HPV), such as types 16 and 18, are thought to be responsible for the development of cervical carcinomas. The E6 and E7 genes of these viruses have transforming activities in various cultured cells and their mRNAs and proteins are expressed in almos