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Mutational analysis of E-cadherin, β-catenin and APC genes in synovial sarcomas

✍ Scribed by Manish Mani Subramaniam; Silvia Calabuig-Fariñas; Antonio Pellin; Antonio Llombart-Bosch


Book ID
110092786
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
300 KB
Volume
57
Category
Article
ISSN
0309-0167

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✍ ILYAS, M.; TOMLINSON, I. P. M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

Much progress has been made in identifying genes mutated during the development of colorectal carcinoma. Mutation of the APC gene in particular appears to be fundamental for colorectal tumour initiation. In contrast, loss of expression of E-cadherin appears to be a late event, which may be important