## Abstract The __Raf/MEK/ERK (MAPK)__ signal transduction cascade is an important mediator of a number of cellular fates including growth, proliferation and survival. The __BRAF__ gene is activated by oncogenic __Ras__, leading to cooperative effects in cells responding to growth factor signals. O
✦ LIBER ✦
The APC/β-catenin pathway in ulcerative colitis–related colorectal carcinomas : A mutational analysis
✍ Scribed by Daniela E. Aust; Jonathan P. Terdiman; Robert F. Willenbucher; Cornell G. Chang; Annette Molinaro-Clark; Gustavo B. Baretton; Udo Loehrs; Frederic M. Waldman
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 81 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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## Abstract There is growing interest in β‐catenin and its role in various human cancers. We recently reported that 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ)‐ and 1,2‐dimethylhydrazine (DMH)‐induced colon tumors in the rat contain mutations in __Ctnnb1__, the gene for β‐catenin, but the muta