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APC, β-catenin, and E-cadherin and the development of recurrent endometrial carcinoma

✍ Scribed by J. M. A. Pijnenborg; N. Kisters; M. Van Engeland; G. A. J. Dunselman; J. De Haan; A. F. P. M. De Goeij; P. G. Groothuis

Book ID
110758753
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
831 KB
Volume
14
Category
Article
ISSN
1048-891X

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✍ ILYAS, M.; TOMLINSON, I. P. M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

Much progress has been made in identifying genes mutated during the development of colorectal carcinoma. Mutation of the APC gene in particular appears to be fundamental for colorectal tumour initiation. In contrast, loss of expression of E-cadherin appears to be a late event, which may be important