Cytoplasmic expression of E-cadherin and β-Catenin correlated with LOH and hypermethylation of the APC gene in oral squamous cell carcinomas
✍ Scribed by Shan Gao; Hans Eiberg; Annelise Krogdahl; Chung-Ji Liu; Jens Ahm Sørensen
- Book ID
- 111253906
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 306 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0904-2512
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In addition to their role in maintenance of tissue integrity, cell adhesion molecules regulate the growth and differentiation of stratified squamous epithelia. Reduced expression of E-cadherin and the 2 1 , 3 1 and 6 4 integrins is already reported to correlate with poor histological differentiation
## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in