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Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: Frequent recovery of triplet mutations

โœ Scribed by Hironobu Ikehata; Fumitaka Yanase; Toshio Mori; Osamu Nikaido; Kiyoji Tanaka; Tetsuya Ono


Book ID
102185162
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
260 KB
Volume
48
Category
Article
ISSN
0893-6692

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Mutation spectrum in UVB-exposed skin ep
โœ Feng Wang; Yusuke Saito; Tadahiro Shiomi; Shogo Yamada; Tetsuya Ono; Hironobu Ik ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 151 KB

A C-terminal 183 amino acid-truncated mutation of the mouse Xpg gene (XpgDeltaex15) gives rise to a partial deficiency in nucleotide excision repair in homozygously affected cells. We studied the effect of this mutation on UVB-induced mutagenesis in mouse skin, using transgenic mice harboring lambda