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Frequent recovery of triplet mutations in UVB-exposed skin epidermis of Xpc-knockout mice

โœ Scribed by Hironobu Ikehata; Yusuke Saito; Fumitaka Yanase; Toshio Mori; Osamu Nikaido; Tetsuya Ono


Book ID
113567780
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
424 KB
Volume
6
Category
Article
ISSN
1568-7864

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Mutation spectrum in UVB-exposed skin ep
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A C-terminal 183 amino acid-truncated mutation of the mouse Xpg gene (XpgDeltaex15) gives rise to a partial deficiency in nucleotide excision repair in homozygously affected cells. We studied the effect of this mutation on UVB-induced mutagenesis in mouse skin, using transgenic mice harboring lambda