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Mutation of K-RAS Protooncogene and Loss of Heterozygosity on 6q27 in Serous and Mucinous Ovarian Carcinomas

โœ Scribed by Mitsuaki Suzuki; Susumu Saito; Yasushi Saga; Michitaka Ohwada; Ikuo Sato

Book ID
114137036
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
158 KB
Volume
118
Category
Article
ISSN
0165-4608

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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit