Genetic changes have been shown to be important in determining the multistep progression of cancer. Allele loss studies and karyotypic analysis of epithelial ovarian tumours have indicated the presence of putative w m u r suppressor genes on chromosomes 6, I I, I 3, 17, I8,22, and X. We have focused
Loss of heterozygosity on chromosome 6q27 and p53 mutations in epithelial ovarian cancer
β Scribed by Mitsuaki Suzuki; Susumu Saito; Yasushi Saga; Michitaka Ohwada; Ikuo Sato
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 558 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1357-0560
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Loss of heterozygosity (LOH) was examined at 27 loci on chromosomes 3p, 6q, I Ip, 13q. 17 and X in 42 human ovarian tumors. LOH was detected in I 2 of 26 (46%) and 5 of I 2 (42%) informative cases at 2 chromosome 13q loci, D13S32 and D I3534 respectively. On chromosome Xp, tumor-specific allele loss
We previously reported the identification of three minimal regions of deletion on the short arm of chromosome 3 (3p) in epithelial ovarian tumor specimens, suggesting that the inactivation of tumor-suppressor genes in these regions may be important in terms of ovarian tumorigenesis. Another previous