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Mutation of CEBPA in Familial Acute Myeloid Leukemia

✍ Scribed by Smith, Matthew L.; Cavenagh, Jamie D.; Lister, T. Andrew; Fitzgibbon, Jude


Book ID
121276428
Publisher
Massachusetts Medical Society
Year
2004
Tongue
English
Weight
366 KB
Volume
351
Category
Article
ISSN
0096-6762

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Mutations of CEBPA in acute myeloid leuk
✍ Jennifer Snaddon; Matthew L. Smith; Michael Neat; Maxine Cambal-Parrales; Amanda πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 445 KB

CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl