Screening for the two most frequent muta
✍
Søren Nørby
📂
Article
📅
1993
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John Wiley and Sons
🌐
English
⚖ 470 KB
This report describes a rapid and inexpensive assay, which allows detection, in whole blood and by PCR alone, of the two most frequent mitochondrial DNA mutations causing Leber's hereditary optic neuropathy. The assay is based on allele-specific amplification, using primers with the mutation-specifi