Asian-specific mtDNA backgrounds associated with the primary G11778A mutation of Leber's hereditary optic neuropathy
โ Scribed by H. Sudoyo; H. Suryadi; P. Lertrit; P. Pramoonjago; D. Lyrawati; S. Marzuki
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 431 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1435-232X
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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m
Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch