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Asian-specific mtDNA backgrounds associated with the primary G11778A mutation of Leber's hereditary optic neuropathy

โœ Scribed by H. Sudoyo; H. Suryadi; P. Lertrit; P. Pramoonjago; D. Lyrawati; S. Marzuki


Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
431 KB
Volume
47
Category
Article
ISSN
1435-232X

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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m

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Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch