## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati
Mutation and allelic loss of the p53 gene in endometrial carcinoma. Incidence and outcome in 92 surgical patients
β Scribed by Toshimasa Kihana; Katsuyuki Hamada; Yasuhiro Inoue; Naoki Yano; Haruhiko Iketani; Shin-Ichi Murao; Masahiko Ukita; Shumpei Matsuura
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 626 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0008-543X
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## Abstract In addition to the loss of function, mutant p53 can possess a dominantβnegative effect on wildβtype p53 and may also exert gainβofβfunction activity. It is not clear whether the functional status of __p53__ mutation contributes to differences in outcome in endometrial cancer. We collect