Mutation analysis of the WT1 gene in secondary leukemia
β Scribed by Takahashi, T; Yamamoto, R; Tanaka, K; Kamada, N; Miyagawa, K
- Book ID
- 110054583
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 123 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0887-6924
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The Wilms' tumor gene WT1, whose loss of function accounts for the genesis of about 10% of Wilms' tumors, is expressed in hematopoietic stem cells and leukemia. By analogy with the relationship between the kidney stem cell and Wilms' tumor, it is probable that WT1 is mutated in leukemia. WT1 mutatio
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