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Mutagenicity of benzo(a)pyrene-3-o-glucuronide, a biliary metabolite of benzo(a)pyrene

โœ Scribed by Chipman, James K.; Millburn, Peter; Brooks, Terry M.

Book ID
123600863
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
89 KB
Volume
17
Category
Article
ISSN
0378-4274

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3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a