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Mutagenicity of 1-, 3- and 6-nitrosobenzo[a]pyrene in Salmonella typhimurium and Chinese hamster ovary cells

โœ Scribed by Robert H. Heflich; Leonard E. Unruh; Janice R. Thornton-Manning; Linda S. von Tungeln; Peter P. Fu


Book ID
113255284
Publisher
Elsevier Science
Year
1989
Weight
493 KB
Volume
225
Category
Article
ISSN
0165-7992

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A strong teratogen-6-aminonicotinamide (6-AN)-was tested for its ability to induce cytotoxicity and mutagenicity in Chinese hamster ovary (CHO) cells. Tests were performed in the presence and absence of a metabolic activation system (S-9 mix). Cytotoxicity was evaluated in CHO cells by the total pro