Molecular characterization of hprt mutat
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De-Jin Zhan; Li-Hsueh Chiu; Robert H. Heflich; Peter P. Fu
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Article
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1998
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John Wiley and Sons
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English
โ 93 KB
๐ 2 views
1-, 3-, and 6-nitrobenzo[a]pyrene (nitro-BaP) are environmental contaminants that can be metabolized to genotoxic derivatives by either nitroreduction or ring-oxidation. In this study, we examined the types of mutations produced by the primary nitroreduced metabolites, 1-, 3-, and 6-nitroso-BaP (NO-