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Muramyl dipeptide potentiates cytokine-induced activation of inducible nitric oxide synthase in rat astrocytes

✍ Scribed by Vladimir Trajkovič; Tatjana Samardžič; Stanislava Stošič-Grujičič; Zorica Ramič; Marija Mostarica Stojkovič

Book ID
113996495
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
326 KB
Volume
883
Category
Article
ISSN
0006-8993

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## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a dose‐dependent increase of NO g