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Nitric oxide induces hydroxyl radical generation in rat hearts via depolarization-induced nitric oxide synthase activation

✍ Scribed by Toshio Obata; Yasumitsu Yamanaka

Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
87 KB
Volume
364
Category
Article
ISSN
0028-1298

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## Abstract Nitric oxide (NO), an important regulatory molecule for immune response and cytotoxicity, is endogenously generated from l‐arginine by NO synthase (NOS). One mechanism for NO‐induced cytotoxicity is through its interaction with superoxide to produce peroxynitrite, which causes DNA damag