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Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes

✍ Scribed by Dj. Miljkovic; T. Samardzic; M. Mostarica Stojkovic; S. Stosic-Grujicic; D. Popadic; V. Trajkovic

Book ID: 113996683
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 802 KB
Volume: 889
Category: Article
ISSN: 0006-8993
DOI: 10.1016/s0006-8993(00)03181-4

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## Abstract Free radical nitric oxide (NO), generated by inducible nitric oxide synthase (iNOS) in astrocytes and macrophages, has been implicated in CNS inflammatory disorders such as multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). Mycophenolic acid (MPA),