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Multistage carcinogenesis and the incidence of human cancer

✍ Scribed by Suresh H. Moolgavkar; E. Georg Luebeck

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
72 KB
Volume
38
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Environmental agents that increase the rate of clonal expansion of partially altered cells are efficient carcinogens. As a corollary, intervention strategies that decrease this rate are to be preferred to strategies that decrease the rate of early mutational events in carcinogenesis. Β© 2003 Wiley‐Liss, Inc.

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