## Abstract We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Env
The multistage theory of carcinogenesis
โ Scribed by Suresh H. Moolgavkar; Matti Hakama; Richard Peto; Richard Doll
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 172 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Carcinogenesis is generally considered to be a multistage process classified under ''initiation,'' ''promotion,'' and ''progression,'' and it is therefore of interest to know how radiation might affect them. Models which are currently being used with some success to analyze a variety of data are bas
Immediate early genes, including fos, jun, and early growth response-1 (Egr-1), are induced during cellular response to changes in extracellular environment. These immediate early genes are believed to mediate processes of cell growth and differentiation. In particular, Egr-1 is induced during mitog