The natural history of carcinogenesis: Implications of experimental carcinogenesis in the genesis of human cancer

✍ Scribed by Pitot, Henry C. ;Goldsworthy, Thomas ;Moran, Susan

• Publisher: Wiley (John Wiley & Sons)
• Year: 1981
• Tongue: English
• Weight: 917 KB
• Volume: 17
• Category: Article
• ISSN: 0275-3723
• DOI: 10.1002/jsscb.380170204

✦ Synopsis

STAGES IN THE NATURAL HISTORY OF CARCINOGENESIS-DEFINITIONS

in relation to our knowledge of human cancer, it is necessary to define and understand the natural history of the development of neoplasia. Since the 1940s carcinogenesis in mouse skin has been divided into the stages of initiation and promotion. Later Foulds, largely on the basis of his studies of mammary carcinogenesis in the mouse [12], proposed the term progression for virtually all of the developmental stages following the initial event in the conversion of a normal to a neoplastic cell. While Foulds saw the natural history of carcinogenesis as a continuous event that could be arbitrarily divided into several phases, modern oncologists take the position that the process of promotion is distinct from that of progression even though each of these phases has been divided into several steps by previous investigators [12, 131.