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Multistage carcinogenesis and the fraction at risk

✍ Scribed by Stephan Morgenthaler; Pablo Herrero; William G. Thilly


Book ID
105998356
Publisher
Springer
Year
2004
Tongue
English
Weight
167 KB
Volume
49
Category
Article
ISSN
0303-6812

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## Abstract We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Env