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Multiplicity in randomised trials II: subgroup and interim analyses

✍ Scribed by Kenneth F Schulz; David A Grimes

Book ID
117289456
Publisher
The Lancet
Year
2005
Tongue
English
Weight
185 KB
Volume
365
Category
Article
ISSN
0140-6736

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πŸ“œ SIMILAR VOLUMES

Multiplicity in randomised trials II: su
Multiplicity in randomised trials II: subgroup and interim analyses
✍ Kenneth F Schulz; David A Grimes πŸ“‚ Article πŸ“… 2005 πŸ› The Lancet 🌐 English βš– 185 KB

Subgroup analyses have specious appeal. They seem logical and intuitive-and even fun-to both investigators and readers. However, this insidious appeal causes important problems. Multiplicity and naivetΓ© combine to encourage interpretational missteps in trial conduct and reporting. The subgroup treat

Interim analyses with delayed observatio
Interim analyses with delayed observations in clinical trials
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The interim analyses based on group sequential procedures are not convenient if the response time relative to the patient accrual rate is long. Since in most trials patients are accrued and randomized continuously, the response data from those already randomized will continue to accumulate when a tr