Multiple sclerosis: a complicated picture of autoimmunity
โ Scribed by McFarland, Henry F; Martin, Roland
- Book ID
- 109923408
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 599 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni1507
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The etiology of multiple sclerosis is linked to a variety of genetic and environmental factors. Both cell-mediated and humoral immune responses, triggered by extraneous or autoantigens, are likely to contribute to the pathogenesis of this disease. A greater insight into the fundamental cause of mult
n experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), T helper 1 (Th1)/Th2 immunological effector pathways are altered. Neuropathological findings and results from MS treatment trials suggest that our view of MS and other putative autoimmune diseases and their