Heat-shock proteins and autoimmunity: Implications for multiple sclerosis
β Scribed by Richard M. Runsohoff; Richard A. Rudich
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 285 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-5134
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## Abstract TCR degeneracy may facilitate selfβreactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC classβII alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.
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