Synthesis of peptide aldehydes on solid
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Marielle Paris; annie Heitz; Vincent Guerlavais; Michèle Cristau; Jean-Alain Feh
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Article
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1998
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Elsevier Science
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French
β 204 KB
A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected or-amino aldehyde with MBHA-supported Wittig ou Winig-Horner reagent yielded resin-linked ~-~-unsaturated 8-amino derivative. After elongation of the peptide chain, ozonolysis produced fair