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Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

✍ Scribed by Miia Turpeinen; Uusitalo Jouko; Jalonen Jorma; Pelkonen Olavi

Book ID
113591415
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
274 KB
Volume
24
Category
Article
ISSN
0928-0987

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In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies
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## Abstract A sensitive and rugged LC/MSMS method was developed for a comprehensive __in vitro__ metabolic interaction screening assay with N‐in‐1 approach reported earlier. A cocktail consisting of ten cytochrome P450 (CYP)‐selective probe substrates with known kinetic, metabolic and interaction p