✦ LIBER ✦

A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates

✍ Scribed by Liu, Li-Ya; Han, Yong-Long; Zhu, Jin-Hui; Yu, Qi; Yang, Quan-Jun; Lu, Jin; Guo, Cheng

Book ID: 125854547
Publisher: John Wiley and Sons
Year: 2014
Tongue: English
Weight: 583 KB
Volume: 29
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.3294

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A sensitive and specific CYP cocktail as

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC–MS/MS

✍ Venkateswaran C. Pillai; Stephen C. Strom; Steve N. Caritis; Raman Venkataramana 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 601 KB

A high-throughput inhibition screening o

A high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry

✍ Qin, Chong-Zhen; Ren, Xian; Tan, Zhi-Rong; Chen, Yao; Yin, Ji-Ye; Yu, Jing; Qu, 📂 Article 📅 2013 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

In vitro assessment of cytochrome P450 i

In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MS-based assay throughput using a one-point IC50 method and multiplexing high-performance liquid chromatography

✍ Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (aut 📂 Article 📅 2007 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 153 KB 👁 1 views

A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec

In vitro assessment of cytochrome P450 i

In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MS-based assay throughput using a one-point IC50 method and multiplexing high-performance liquid chromatography

✍ Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (aut 📂 Article 📅 2007 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 153 KB 👁 1 views

A SENSITIVE AND HIGH-THROUGHPUT LC/MS/MS

A SENSITIVE AND HIGH-THROUGHPUT LC/MS/MS METHOD USING A SILICA COLUMN AND AN AQUEOUS-ORGANIC MOBILE PHASE FOR THE ANALYSIS OF FLUOXETINE AND NORFLUOXETINE IN HUMAN PLASMA

✍ Eerkes, Angela; Weng, Naidong; King, Melissa; Du, Alicia; Shou, Wilson Z. 📂 Article 📅 2002 🏛 Taylor and Francis Group 🌐 English ⚖ 200 KB

An in-vitro validation study in the fiel

An in-vitro validation study in the field of toxicokinetics and metabolism: Validation of an LC–MS/MS assay for simultaneous assessment of cytochrome P450 activity using cryopreserved human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, CYP2C9 and CYP1A2

✍ E. Bourgogne; G. Saucez; S. Dell’Aiera; M. rosa; C. Jacques-hespel; B. Gerin; H. 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 83 KB