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In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MS-based assay throughput using a one-point IC50 method and multiplexing high-performance liquid chromatography

โœ Scribed by Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (author)

Publisher
John Wiley and Sons Inc.
Year
2007
Tongue
English
Weight
153 KB
Volume
96
Category
Article
ISSN
0022-3549

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In vitro assessment of cytochrome P450 i
In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MS-based assay throughput using a one-point IC50 method and multiplexing high-performance liquid chromatography
โœ Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (aut ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 153 KB ๐Ÿ‘ 1 views

A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec