Multiple Myeloma: Lusting for NF-κB
✍ Scribed by Thomas D. Gilmore
- Book ID
- 113523762
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 196 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1535-6108
No coin nor oath required. For personal study only.
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Multiple myeloma is still not curable and drug combination strategies are currently being evaluated in order to achieve high remission rates with tolerable toxicity. Bortezomib has been shown to exert inhibitory effects on NFB activity. NFB in turn is known to be activated by cytokines, growth facto
Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we successfully target NF-kappaB with a novel NF-kappaB i