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Cardamonin exerts potent activity against multiple myeloma through blockade of NF-κB pathway in vitro

✍ Scribed by You Qin; Chun-Yan Sun; Fu-Rong Lu; Xiang-Rong Shu; Di Yang; Lei Chen; Xiao-Mei She; Nicholas Miller Gregg; Tao Guo; Yu Hu

Book ID
113773615
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
946 KB
Volume
36
Category
Article
ISSN
0145-2126

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Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we successfully target NF-kappaB with a novel NF-kappaB i