Expression of receptor activator of NF-κB ligand (RANKL) mRNA in human multiple myeloma cells
✍ Scribed by Ulrike Heider; Ivana Zavrski; Christian Jakob; Katharina Bängeroth; Claudia Fleissner; Corinna Langelotz; Kurt Possinger; Lorenz C. Hofbauer; Volker Viereck; Orhan Sezer
- Book ID
- 106123377
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 258 KB
- Volume
- 130
- Category
- Article
- ISSN
- 1432-1335
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## Abstract The receptor activator of nuclear factor‐kappaB ligand (RANKL) and interleukin‐1beta are osteoclast activating factors which are abnormally expressed in bone marrow stromal cells and plasma cells of multiple myeloma patients. In this work we analyzed RANKL expression in human bone marro
Multiple myeloma is still not curable and drug combination strategies are currently being evaluated in order to achieve high remission rates with tolerable toxicity. Bortezomib has been shown to exert inhibitory effects on NFB activity. NFB in turn is known to be activated by cytokines, growth facto