The upregulation of receptor activator NF-κB ligand expression by interleukin-1α and Porphyromonas endodontalis in human osteoblastic cells
✍ Scribed by S.-C. Chen; F.-M. Huang; S.-S. Lee; M.-Z. Li; Y.-C. Chang
- Book ID
- 108784618
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 213 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0143-2885
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## Abstract Expression of the cytokine, receptor activator of NF‐κB ligand (RANKL), is stimulated by both parathyroid hormone (PTH) and calcitriol in osteoblasts. Most studies have examined the effects on RANKL mRNA, and less information is available on the protein products. We have determined the
## Background: The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. however, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. receptor activator of nf-kappab ligand (rankl), macropha