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Multiple hepatic excretory pathways studied in mutant rats with defective biliary anion excretion


Book ID
122952109
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
86 KB
Volume
1
Category
Article
ISSN
0168-8278

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Dubin-Johnson patients, mutant Corriedale sheep and TRand EHBR mutant rats have recessively inherited defective bile canalicular secretion of many nonbile acid organic anions. The human and ovine mutants have black livers and lysosomal pigment accumulation. The livers in TR-and EHBR mutant rats are