✦ LIBER ✦

Multiple genetic events involving rbi gene deletion and amplification of chromosome 21 in a case of acute lymphocytic leukemia

✍ Scribed by Yie Liu; Mats Heyman; Dan Grandér; Stefan Einhorn; Dr. Stefan Söderhäll; Karen Bröndum-Nielsen

Book ID: 102221878
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 320 KB
Volume: 9
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870090113

No coin nor oath required. For personal study only.

✦ Synopsis

A patient with acute lymphocytic leukemia was found to have a hyperdiploid karyotype, characterized by hexasomy 21 and del(7)(pI 5). I t was shown that the four extra copies of chromosome 21 were all derived from only one of the homologous chromosomes. Molecular analysis showed that the patient had a deletion of both alleles of the retinoblastoma (RBI) gene. These results suggest that multiple events, including loss of RBI gene function and amplification of a key gene(s) on chromosome 2 I, have contributed to the leukemic transformation.

📜 SIMILAR VOLUMES

Amplification of the AML1(CBFA2) gene on

Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

✍ Berthold Streubel; Peter Valent; Klaus Lechner; Christa Fonatsch 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 448 KB

A cryptic three-way translocation involv

A cryptic three-way translocation involving chromosomes 8, 14, and 21 in a case of acute myeloid leukemia subtype M1

✍ Lai-Ching Lau; Liang-Piu Koh; Tse-Hui Lim; Li-Eng Loo; Sim-Leng Tien 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 217 KB

A complex rearrangement involving crypti

A complex rearrangement involving cryptic deletion of ETV6 and CDKN1B genes in a case of childhood acute lymphoblastic leukemia

✍ Aleksandra Drago Krstic; Luciana Impera; Marija Guc-Scekic; Nina Lakic; Dragan D 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 543 KB

Rearrangement of one RAR-α gene in an ac

Rearrangement of one RAR-α gene in an acute promyelocytic leukemia case with t(15;17) and t(6;17) involving chromosomes 17 band q21

✍ E. Arranz; J.L. López; M. Robledo; B. Martínez; A. Escudero; J. Benítez 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 547 KB

Deletion of TET2 gene in an acute myeloi

Deletion of TET2 gene in an acute myeloid leukemia case with a t(4;15)(q24;q26) characterized by glass needle based chromosome microdissection and oligonucleotide array

✍ Olaya Villa; Mar Mallo; Nadezda Kosyakova; Marta Salido; Thomas Liehr; Luz Martí 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 283 KB

Deletion of MYC and presence of double m

Deletion of MYC and presence of double minutes with MYC amplification in a morphologic acute promyelocytic leukemia–like case lacking RARA rearrangement: could early exclusion of double-minute chromosomes be a prognostic factor?

✍ John L. Frater; Richard G. Hoover; Kristen Bernreuter; Jacqueline R. Batanian 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 230 KB