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Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

✍ Scribed by Berthold Streubel; Peter Valent; Klaus Lechner; Christa Fonatsch


Book ID
114134956
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
448 KB
Volume
124
Category
Article
ISSN
0165-4608

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Amplification of the MLL gene on double
✍ Berthold Streubel; Peter Valent; Ulrich JΓ€ger; Martin EdelhΓ€user; Hannes Wandt; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 184 KB πŸ‘ 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi