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Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia

✍ Scribed by Arabella Smith; Luke St. Heaps; Praveen Sharma; Angela Jarvis; Cecily Forsyth


Book ID
114135133
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
388 KB
Volume
130
Category
Article
ISSN
0165-4608

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Amplification of the MLL gene on double
✍ Berthold Streubel; Peter Valent; Ulrich JΓ€ger; Martin EdelhΓ€user; Hannes Wandt; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 184 KB πŸ‘ 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi