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Amplification on double-minute chromosomes and partial-tandem duplication of the MILL gene in leukemic cells of a patient with acute myelogenous leukemia

✍ Scribed by Yoji Ariyama; Yoji Fukuda; Yoshiaki Okuno; Masao Seto; Kose Date; Tatsuo Abe; Yusuke Nakamura; Johji Inazawa


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
588 KB
Volume
23
Category
Article
ISSN
1045-2257

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Amplification of the MLL gene on double
✍ Berthold Streubel; Peter Valent; Ulrich JΓ€ger; Martin EdelhΓ€user; Hannes Wandt; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 184 KB πŸ‘ 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi