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Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells

✍ Scribed by Pontus Strålin; Stefan L Marklund


Book ID
119438724
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
172 KB
Volume
151
Category
Article
ISSN
0021-9150

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Cultured rat vascular smooth muscle cells (VSMCs) produce nitric oxide (NO) under stimulation by lipopolysaccharide (LPS) and interferon-y (IFN-y). NO synthase (NOS) and manganese superoxide dismutase (Mn-SOD) mRNA expressions are simultaneously induced by these stimulants in rat VSMCs. In VSMCs, S-