Nitric oxide releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of manganese superoxide dismutase mRNA in rat vascular smooth muscle cells
✍ Scribed by Hiroaki Sano; Makoto Hirai; Hidehiko Saito; Izumi Nakashima; Ken-ichi Isobe
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 512 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Cultured rat vascular smooth muscle cells (VSMCs) produce nitric oxide (NO) under stimulation by lipopolysaccharide (LPS) and interferon-y (IFN-y). NO synthase (NOS) and manganese superoxide dismutase (Mn-SOD) mRNA expressions are simultaneously induced by these stimulants in rat VSMCs. In VSMCs, S-nitroso-N-acetyl penicillamine (SNAP), one of the NO releasing reagents, induces Mn-SOD mRNA which may protect the VSMCs themselves. This suggests that NO itself may enhance the expression of Mn-SOD to protect the VSMC themselves against NO radicals in cultured rat VSMCs.